Contact Information

(267) 519-4824

M. Hakan Ozdener

Research Associate

Education

M.D., Ondokuz Mayis University, Samsun, Turkey
Ph.D., Biochemistry; Ondokuz Mayis University, Samsun Turkey, -ICGEB, New Delhi India
MPH, (Public Health); Temple University

Research Summary

My primary research focuses on the development of in vitro chemosensory cell culture systems for the study of chemosensory biology and disorders. I utilize chemosensory cells obtained from human and from rodent to examine the factors involved in differentiation and maturation and to better understand how chemosensory receptor cells interact in their responses to stimuli. This work will enable us to develop and characterize novel tastent and new therapeutic targets to promote regeneration following injury from surgery, radiation, toxic exposures or deterioration due to aging or neurodegenerative disease.

Keywords

taste cell, olfactory cells, development, cell culture, chemosensory cells and infection

Recent Publications

Ozdener, M. H.; Rawson, N. E. (In Press) Exogenous EGF and BDNF treatment triggered cultured taste cell differentiation and proliferation. Turkish Journal of Medical Sciences.

Ozdener, M. H.; Rawson, N. E. (2011) Culture and maintenance of taste cells in vitro. In Vitro Cellular & Developmental Biology: Animal. July.

Ozdener, M. H.; Brand, J. G.; Spielman, A.; Lischka, F. W.; Teeter, J. H.; Breslin, P. A. S. and Rawson, N.E. (2011) Method for long term primary culture of human fungiform taste bud cells in culture. Chemical Senses. 36.7, 601-12.

Jaén, C., Ozdener, M. H., and Reisert, J. (2011, electronic citation). Mechanisms of chloride uptake in frog olfactory receptor neurons. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology.

Mandel, A. L., Ozdener, M. H., and Vainius, A. A. (2011). Brain-derived neurotrophic factor in human saliva: ELISA optimization and biological correlates. Immunoassay and Immunochemistry, 32, 18-30.

Ozdener, M. H., Brand, J. G., Speilman, F. G., Lischka, F. W., Teeter, J., Breslin, P. A. S., and Rawson, N. E. (2011, electronic citation). Characterization of human fungiform papillae cells in culture. Chemical Senses, doi:10.1093/chemse/bjr012.

Dalton, P. H., Opiekun, R. E., Gould, M., McDermott, R., Wilson, T., Maute, C., Ozdener, M. H., Zhao, K., Emmett, E., Lees, P. S., Herbert, R., and Moline, J. (2010). Chemosensory loss: functional consequences of the World Trade Center disaster. Environmental Health Perspectives, 118, 1251-1256.

M.H. Ozdener,, KK Yee, R McDermott, B.J. Cowart, A.A. Vainius, P. Dalton, N.E. Rawson. Assessment of Smoking Status Based on Cotinine Levels in Nasal Lavage Fluid. Tobacco Induced Diseases. 2009 Jul 3;5(1):11.

A.L. Mandel, H. Ozdener, V. Utermohlen. Identification of Pro- and Mature Brain- Derived Neurotrophic Factor in Human Saliva. Arch Oral Biol. 2009 Jul;54(7):689-95

K. E. Borgmann-Winter, N. E. Rawson, H-y Wang, H. Wang, M. L. MacDonald, M. H. Ozdener, K. K. Yee, G. Gomez, J. Xu, B. Bryant, G. Adamek, N. Mirza, E. Pribitkin, C-G. Hahn. Human olfactory epithelial cells generated in vitro differentiate to express a diversity of neuronal functions. Neuroscience 2009 Jan 23;158(2):642-53.

Nancy E. Rawson, M. Hakan Ozdener. In vitro models to study taste: Can sweetness be modeled in a dish? In Sweetness and Sweeteners Biology, Chemistry and Psychophysics. Edited by: DK Weerasinghe and GE DuBois. American Chemical Society symposium series 979. pp 76-93. Oxford University Press 2008 ISBN: 978-0-8412-7432-7

H. Ozdener Inducible functional expression of Bcl-2 in human astrocytes derived from NTera-2 cells. J Neurosci Methods. 2007 Jan 15;159(1):8-18.

Ozdener H, Yee KK, Cao J, Brand JG, Teeter JH, Rawson NE. Characterization and long-term maintenance of rat taste cells in culture. Chem Senses. 2006 Mar;31(3):279-90