|
My primary
research interest is to understand the molecular and
cellular bases of taste and smell disorders. Although
rapid progress has been made
in identifying chemosensory receptors and signaling
proteins, the mechanisms of chemosensory disorders remain
largely unknown. My current research
projects include: 1) characterizing pathways of inflammatory
cytokines and Toll-like receptors (TLRs) in chemosensory
systems; 2) determining
the effects of inflammation on taste bud cell degeneration
and regeneration; 3) identifying regulatory mechanisms
that alter chemosensory signaling
in animal models of inflammation; and 4) investigating
the interactions between inflammatory pathways and taste
receptor-mediated signaling
pathways in enteroendocrine cells in the gut.
My Monell Publications |