Graeme Lowe
Associate Member

Ph.D.
(Physics; California Institute of Technology)

I am interested in the cellular neurophysiology of sensory coding and signal processing in the vertebrate olfactory system. Current research in my laboratory is focused on characterizing mechanisms of synaptic transmission and dendritic computation in the olfactory bulb, the first major processing center in the olfactory system. By analyzing the physiology and biophysics of the neuronal circuitry of the bulb, I seek to define the kinds of elementary logical operations available to this neural network. My long-term goal is to understand how these mechanisms cooperate to determine the neuronal dynamics involved in the transformation, synthesis and storage of odor representations. I am also interested in applying imaging techniques to investigate adaptation properties and odor mixture processing in the olfactory system. Experimental approaches used in my laboratory include multielectrode patch clamp, laser flash photolysis and optical recording applied to both in vitro and in vivo model systems.