Mutagenesis Centers

ENU Mutagenesis Programme

http://www.mgc.har.mrc.ac.uk/mutabase/

This site is based in Harwell, UK. It provides a detailed method for screening mice for behavioral abnormalities (the SHIRPA protocol), monthly updates of mice with abnormal phenotypes, a list of mutation map positions, and a list of collaborators and their projects.

Jackson Labs Mutagenesis Program

http://www.jax.org/nmf/ and http://www.jax.org/hlbs/documents/about_hlbs.html

Not one, but two mutagenesis programs. The first link is for neuroscience-related phenotypes, the second for Heart, Lung, Blood, and Sleep.

Oakridge National Laboratory

http://www.bio.ornl.gov/htpages/mgd/mouse_fac.htmlx

One page description, with access to a mutant mouse database.

German ENU Mouse Mutagenesis Screen Project

http://www.gsf.de/isg/groups/enu-mouse.html

This site, written in English, is part of the German Human Genome Project. There is a short description of the project justification, an organizational chart that provides an idea of the screens used, and a list of ~200 mutants identified, arranged by deficit.

Baylor College of Medicine Mouse Genome Project

http://www.mouse-genome.bcm.tmc.edu/ENU/ENUHome.asp

Specializing in mutagenesis targeted to Chromosome 11 and affecting development.

Mutagenesis Project at MRI

http://www.montana.edu/wwwmri/enump.html

This project at the McLaughlin Research Institute focuses on mutations in genes that are relevant to the functions of amyloid precursor protein or prion protein. The site gives a sketch of the protocol, including a table of behaviors screened, and a list of ~25 mutations found.

Ricken Mutagenesis Center

http://www.gsc.riken.go.jp/Mouse/

The Japanese Center. This site has a good explanation of the protocol, great pictures, and a searchable mutant mouse database.

Methods Paper

Robert W. Williams. A Targeted Screen to Detect Recessive Mutations that have Quantitative Effects. Excellent, detailed description of breeding protocols, including a cost analysis. http://www.nervenet.org/papers/Consomic.html

Trans-NIH Mouse Initiative FAQ

http://www.nih.gov/science/models/mouse/funding/rfa_mmpdd_briefing.html