Contact Information

(267) 519-4894

Ambarish Ghatpande

Research Associate

Education

Ph.D., Molecular Biophysics; Indian Institute of Science

Research Summary

I am interested in multiple aspects of mammalian olfaction. My current research focuses on the physiology and function of cellular and synaptic elements of the olfactory bulb targeted by the neurotransmitters acetylcholine and nitric oxide. In my experiments, I predominantly use patch clamp and optical techniques to record physiological signals from transgenic and wild type mouse brain slices.

The long-term goal of this research is to gain mechanistic insight into olfactory coding and memory. At a broader level this work has the potential to improve our understanding of brain dysfunction in disorders like dementia or schizophrenia.

Keywords

Neurophysiology, synaptic transmission, olfactory memory, neuronal and synaptic correlates of cognition, neurodegenerative disease

Recent Publications

McQuade, L.E., Ma, J., Lowe, G., Ghatpande A., Gelperin A., Lippard, S.J. (2010) Visualization of nitric oxide production in the mouse main olfactory bulb by a cell-trappable copper (II) fluorescent probe. Proc. Natl. Acad. Sci. USA 107, 8525-8530.

Gelperin, A. & Ghatpande, A. (2009) Neural basis of olfactory perception. Annals of the New York Academy of Sciences, 1170, 277-285.

Ghatpande, A. S. & Gelperin, A. (2009) Presynaptic muscarinic receptors enhance glutamate release at the mitral/tufted to granule cell dendrodendritic synapse in the rat main olfactory bulb. Journal of Neurophysiology, 101, 2052-2061.

Ghatpande A.S. (2009) Is the olfactory bulb computationally similar to the retina? Journal of Neurophysiology. 101, 1-4.