Bedrich Mosinger

Senior Research Associate

Education

M.D., Charles University (Prague, Czech Republic)
Ph.D. Genetics; Czechoslovak Academy of Sciences

Research Summary

I am interested in the role of taste signaling proteins outside of the taste system: in nutrition, metabolism and endocrine system. I also have a long-term interest in experimental genetics – in developing genetic models to study function of genes.

Keywords

genetics, molecular biology, endocrine function, metabolism, signaling molecules

Recent Publications

Maillet, E. L., Margolskee, R. F., & Mosinger, B. (2009, electronic publication). Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3. Journal of Medicinal Chemistry. doi: 10.1021/jm900823s.

Kokrashvili Z, Mosinger B, Margolskee RF. Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones. Am J Clin Nutr. 2009. July 1 [Epub ahead of print]

Kokrashvili Z, Rodriguez D, Yevshayeva V, Zhou H, Margolskee RF, Mosinger B. Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5. Gastroenterology. 2009 Aug;137(2):598-606, 606.e1-2. Epub 2009 Mar 9.

Kokrashvili, Z., Mosinger, B., & Margolskee, R. F. (2009). T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1. Annals of the New York Academy of Sciences, 1170, 91-94.

Damak S, Mosinger B, Margolskee RF. Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice. BMC Neurosci. 2008 Oct 2;9:96.

Tordoff MG, Shao H, Alarcón LK, Margolskee RF, Mosinger B, Bachmanov AA, Reed DR, McCaughey S. Involvement of T1R3 in calcium-magnesium taste. Physiol Genomics. 2008 Aug 15;34:338-48.

Jang, H.J., Kokrashvili, Z., Theodorakis, M.J., Carlson, O.D., Kim, B.J., Xu, X., Chan, S.L., Juhaszova, M.,Bernier, M., Mosinger, B., Margolskee, R.F., Egan, J. Gut-expressed taste receptors regulate secretion of glucagon-like peptide-1. Proc. Natl. Acad. Sci, USA, 2007, 104: 15069-74.

Margolskee, R.F., Dyer, J., Kokrashvili, Z., Salmon, K.S.H, Ilegems, E., Mosinger, B., Shirazi-Beechey, S. (2007) Gut-expressed sweet taste receptor senses dietary sugars to regulate glucose absorption. Proc.Natl. Acad. Sci, USA, 2007, 104: 15075-80.

Charrier E, Mosinger B, Meissirel C, Aguera M, Rogemond V, Reibel S, Salin P, Chounlamountri N, Perrot V, Belin MF, Goshima Y, Honnorat J, Thomasset N, Kolattukudy P. Transient alterations in granule cell proliferation, apoptosis and migration in postnatal developing cerebellum of CRMP1-/- mice. Genes Cells. 2007,11:1337-52.