Contact Information

(267) 519-4672
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Bedrich Mosinger

Affiliations

Senior Research Associate, Monell Chemical Senses Center

Education

M.D., Charles University (Prague, Czech Republic)
Ph.D. Genetics; Czechoslovak Academy of Sciences

Research Summary

I am interested in the role of taste signaling proteins outside of the taste system: in nutrition, metabolism and endocrine system. I also have a long-term interest in experimental genetics – in developing genetic models to study function of genes.

Keywords

genetics, molecular biology, endocrine function, metabolism, signaling molecules

Recent Publications

Yamashita, N; Mosinger, B.; Roy, A.; Miyazaki, M.; Ugajin, K.; Nakamura, F.; Sasaki, K.; Yamaguchi, K.; Kolattukudy, P. and Goto, A. (2011) “CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.” Journal of Neuroscience. 35.5, 1773-79.

Kokrashvili, Z.; Mosinger, B. and Margolskee, R. F. (2009) “Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.” American Journal of Clinical Nutrition. 90.3, 822S-5S.

Kokrashvili, Z.; Rodriguez, D.; Yevshayeva, V.; Zhou, H.; Margolskee, R. F. and Mosinger, B. (2009) “Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.” Gastroenterology. 137.2, 598-606.

Kokrashvili, Z.; Mosinger, B. and Margolskee, R. F. “T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.” Annals of the New York Academy of Sciences. 1170, 91-94.

Maillet, E. L.; Margolskee, R. F. and Mosinger, B. (2009) “Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.” Journal of Medicinal Chemistry. 12, 6931-35.

Damak, S.; Mosinger, B. and Margolskee, R. F. (2008) “Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice.” BMC Neuroscience. 9, 96.

Tordoff, M. G.; Shao, H.; Alarcón, L. K.; Margolskee, R. F.; Mosinger, B.; Bachmanov, A. A.; Reed, D. R. and McCaughey, S. A. (2008) “Involvement of T1R3 in calcium-magnesium taste.” Physiological Genomics. 34.3, 338-48.

Jang, H. J.; Kokrashvili, Z.; Theodorakis, M. J.; Carlson, O. D.; Kim, B. J.; Zhou, J.; Kim, H. H.; Xu, X.; Chan, S. L.; Juhaszova, M.; Bernier, M.; Mosinger, B.; Margolskee, R. F. and Egan, J. M. (2007) “Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.” Proceedings of the National Academy of Sciences USA. 104.38, 15069-74.

Margolskee, R. F.; Dyer, J.; Kokrashvili, Z.; Salmon, K. S.; Ilegems, E.; Daly, K.; Maillet, E. L.; Ninomiya, Y.; Mosinger, B. and Shirazi-Beechey, S. P. (2007) “T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.” Proceedings of the National Academy of Sciences USA. 104.38, 15075-80.