Contact Information

(267) 519-4672
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Bedrich Mosinger

Affiliations

Senior Research Associate, Monell Chemical Senses Center

Laboratory of

Dr. Robert Margolskee

Education

M.D., Charles University (Prague, Czech Republic)
Ph.D. Genetics; Czechoslovak Academy of Sciences

Research Summary

I am interested in the role of taste signaling proteins outside of the taste system: in nutrition, metabolism and endocrine system. I also have a long-term interest in experimental genetics – in developing genetic models to study function of genes.

Keywords

genetics, molecular biology, endocrine function, metabolism, signaling molecules

Recent Publications

Kokrashvili Z, Yee KK, Ilegems E, Iwatsuki K, Li Y, Mosinger B, Margolskee RF. Endocrine taste cells. Br J Nutr. 2014 Jun;111 Suppl 1:S23-9. Epub 2014 Jan 2.

Mosinger B, Redding KM, Parker MR, Yevshayeva V, Yee KK, Dyomina K, Li Y, Margolskee RF. Genetic loss or pharmacological blockade of testes-expressed taste genes causes male sterility. Proc Natl Acad Sci USA. 2013 Jul 23;110(30):12319-24.

Li Y, Kokrashvili Z, Mosinger B, Margolskee RF. Gustducin couples fatty acid receptors to GLP-1 release in colon. Am J Physiol Endocrinol Metab. 2013 Mar 15;304(6):E651-60.

Yamashita, N; Mosinger, B.; Roy, A.; Miyazaki, M.; Ugajin, K.; Nakamura, F.; Sasaki, K.; Yamaguchi, K.; Kolattukudy, P. and Goto, A. (2011) “CRMP5 (collapsin response mediator protein 5) regulates dendritic development and synaptic plasticity in the cerebellar Purkinje cells.” Journal of Neuroscience. 35.5, 1773-79.

Kokrashvili, Z.; Mosinger, B. and Margolskee, R. F. (2009) “Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.” American Journal of Clinical Nutrition. 90.3, 822S-5S.

Kokrashvili, Z.; Rodriguez, D.; Yevshayeva, V.; Zhou, H.; Margolskee, R. F. and Mosinger, B. (2009) “Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.” Gastroenterology. 137.2, 598-606.

Kokrashvili, Z.; Mosinger, B. and Margolskee, R. F. “T1r3 and alpha-gustducin in gut regulate secretion of glucagon-like peptide-1.” Annals of the New York Academy of Sciences. 1170, 91-94.

Maillet, E. L.; Margolskee, R. F. and Mosinger, B. (2009) “Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.” Journal of Medicinal Chemistry. 12, 6931-35.

Damak, S.; Mosinger, B. and Margolskee, R. F. (2008) “Transsynaptic transport of wheat germ agglutinin expressed in a subset of type II taste cells of transgenic mice.” BMC Neuroscience. 9, 96.

Tordoff, M. G.; Shao, H.; Alarcón, L. K.; Margolskee, R. F.; Mosinger, B.; Bachmanov, A. A.; Reed, D. R. and McCaughey, S. A. (2008) “Involvement of T1R3 in calcium-magnesium taste.” Physiological Genomics. 34.3, 338-48.

Jang, H. J.; Kokrashvili, Z.; Theodorakis, M. J.; Carlson, O. D.; Kim, B. J.; Zhou, J.; Kim, H. H.; Xu, X.; Chan, S. L.; Juhaszova, M.; Bernier, M.; Mosinger, B.; Margolskee, R. F. and Egan, J. M. (2007) “Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.” Proceedings of the National Academy of Sciences USA. 104.38, 15069-74.

Margolskee, R. F.; Dyer, J.; Kokrashvili, Z.; Salmon, K. S.; Ilegems, E.; Daly, K.; Maillet, E. L.; Ninomiya, Y.; Mosinger, B. and Shirazi-Beechey, S. P. (2007) “T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1.” Proceedings of the National Academy of Sciences USA. 104.38, 15075-80.