Contact Information

(267) 519-4840
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Charles J. Wysocki

Affiliations

Member, Monell Chemical Senses Center
Adjunct Professor, Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania

Education

Ph.D., Psychobiology (Neuroscience); Florida State University

Research Summary

Individuals differ quite substantially in their ability to smell myriad odorants. In some instances a person may not be able to detect an odor when others in the group can clearly perceive it. In other situations all may detect an odor but there is considerable disagreement about what it smells like. I explore this variation at different levels of analyses, e.g., genetic influences, gender differences and the impacts of age and the environment on odor perception. In another area of research I have explored the effects of body odor on the physiology and behavior of individuals who are exposed to the odor. Even among humans there is mounting evidence that we communicate information about ourselves to others via pheromones (chemical communication), often at a subconscious level. This information can be used to identify individuals, to alter hormone systems and to modify mood and emotion.

Keywords

olfaction, vomereonasal, chemical communication, pheromones, intranasal, chemesthesis, psychophysics, behavioral genetics, adaptation/cross-adaptation, behavioral neuroscience, histology

Recent Publications

Olender, T.; Waszak, S.M.; Viavant, M.; Khen, M.; Ben-Asher, E.; Reyes, A.; Nativ, N.; Wysocki, C.J.; et al. (2012) Personal receptor repertoires: olfaction as a model. BMC Genomics, 13.

Knaapila, A.; Hwang, L.D.; Lysenko, A.; Duke, F.F.; Fesi, B.; Khoshnevisan, A.; Wysocki, C.J.; et al. (2012) Genetic analysis of chemosensory traits in human twins. Chemical Senses, 37, 869-881.

Wise, P.M.; Wysocki, C.J.; Lundström, J.N. (2012) Stimulus selection for intranasal sensory isolation: eugenol is an irritant. Chemical Senses, 37, 509-514.

Voznessenskaya, V.V.; Klyuchnikova, M.K.; Wysocki, C.J. (2010) Roles of the main olfactory and vomeronasal systems in the detection of androstenone in inbred strains of mice. Current Zoology, 56, 813-818.

Williams, A.L.; Heineman, P.H.; Wysocki, C.J.; et al. (2010) Prediction of odor pleasantness using electronic nose technology and artificial neural networks. Applied Engineering in Agriculture, 26, 343-350.

Wise, P.M.; Zhao, K.; Wysocki, C.J. (2010) Dynamics of nasal irritation from pulsed homologous alcohols. Chemical Senses, 35, 823-829.

Wysocki, C.J.; Preti, G. (2010) Human Pheromones: What’s Purported, What’s Supported. A Sense of Smell Institute White Paper. The Fragrance Foundation: New York.

Wise, P.M.; Zhao, K.; Wysocki, C.J. (2009) Dynamics of nasal chemesthesis. Annals of the New York Academy of Science, 1170, 206-214.

Wise, P.M.; Toczydlowski, S.E.; Zhao, K.; Wysocki, C.J. (2009) Temporal integration in nasal lateralization of homologous propionates. Inhalation Toxicology, 21, 819-827.

Wysocki, C.J.; Preti, G. (2009) Pheromones in Mammals. In: L.R. Squire. (Ed.) Encylcopedia of Neuroscience. Oxford: Academic Press, 7, 625-632.

Wysocki, C.J.; Louie, J.; Leyden, J.J.; Blank, D.; Gill, M.; Smith, L.; McDermott, K.; Preti, G. (2009) Cross-adaptation of a model human stress-related odor with fragrance chemicals and ethyl esters of axillary odorants: gender-specific effects. Flavour and Fragrance Journal, 24, 209-216.

Gallagher, M.; Wysocki, C.J.; Leyden, J.J.; Spielman, A.I.; Sun, X.; Preti,G. (2008) Analyses of volatile organic compounds from human skin. British Journal of Dermatology, 159, 780-791.