Member, Monell Chemical Senses Center
Ph.D., Psychology; Yale University
Quantitative genetics is concerned with the inheritance of those differences between individuals that are of a degree rather than of a kind; for instance, the threshold at which someone can experience bitterness or an odorant, or the degree of pleasure that comes from tasting sugars. An understanding of these differences is of fundamental significance and has led to important insights about the molecular mechanisms that underpin the biology of obesity, nutrition, taste and smell.
The focus of my work has been to understand the precise relationship between genotype and phenotype in both humans and rodents, as well as how development and environment can affect those relationships. This research is pursued using linkage analysis and association methods, both of which exploit the behavior of chromosomes during meiosis.
My collaborators and I have conducted projects with linkage analysis for saccharin preference in mice followed by positional cloning, which uncovered a protein that is now known to be the subunit of a sweet receptor (Tas1r3). Similar types of human family-based linkage studies assisted in the identification of a receptor on human chromosome 5 (TAS2R1), which is involved in the perception of the bitter compound propylthiouracil. Likewise, association studies helped to define how haplotypes of the bitter receptor TAS2R38 affect bitter taste perception.
Our ongoing work is aimed at understanding the heritability and molecular underpinnings of obesity and fat patterning; perceived sweet intensity of human twins; the relationship between olfactory receptor genotype and smell phenotypes; and the developmental aspects of genotype-phenotype relationships in human children.Detailed description of research program
sweet, genetics, taste, smell, obesity, genomics, genetic mapping
Jiang, P.; Josue-Almqvist, J.; Jin, X.; Li, X.; Brand, J.; Margolskee, R.; Reed, D.; Beauchamp, G. (In Press) The bamboo-eating giant panda (Ailuropoda melanoleuca) has a sweet tooth: Behavioral and molecular responses to compounds that taste sweet to humans. PLoS One.
Bachmanov, A.A.; Bosak, N.P.; Lin, C.; Matsumoto, I.; Ohmoto, M.; Reed, D.R.; Nelson, T.M. (In press) Genetics of taste receptors. Current Pharmaceutical Design, PMID: 23886383
Adappa, N.D.; Howland, T.J.; Palmer, J.N.; Kennedy, D.W.; Doghramji, L.; Lysenko, A.; Reed, D.R.; Lee, R.J.; Cohen, N.A. (In Press) Genetics of the taste receptor T2R38 correlates with chronic Rhinosinusitis necessitating surgical intervention. International Forum of Rhinology and Allergy Journal. doi: 10.1002/alr.21140.
Lin, C.; Theodorides, M.L.; McDaniel, A.H.; Tordoff, M.G.; Zhang, Q.; Li, X.; Bosak, N.; Bachmanov, A.A.; Reed, D.R. (2013) QTL analysis of dietary obesity in C57BL/6ByJ X 129P3/J F2 mice: diet- and sex-dependent effects. PloS ONE, 8, e68776.
Lipchock, S.V.; Mennella, J.A.; Spielman, A.I.; Reed, D.R. (2013) Human bitter perception correlates with bitter receptor messenger RNA expression in taste cells. American Journal of Clinical Nutrition, 98, 1136-1143.
Newcomb, R.D.; Xia, M.B.; Reed, D.R. (2012) Heritable differences in chemosensory ability among humans, Flavour, 1.
Mennella, J.A.; Finkbeiner, S.; Reed, D.R. (2012) The proof is in the pudding: children prefer lower fat but higher sugar than do mothers. International Journal of Obesity (London), 36, 1285-1291.
Lipchock, S.V.; Reed, D.R.; Mennella, J.A. (2012) Relationship between bitter-taste receptor genotype and solid medication formulation usage among young children: a retrospective analysis. Clinical Therapeutics, 34, 728-733.
Lee, R.J.; Xiong, G.; Kofonow, J.M.; Chen, B.; Lysenko, A.; Jiang, P.; Abraham, V.; Doghramji, L.; Adappa, N.D.; Palmer, J.N.; Kennedy, D.W.; Beauchamp, G.K.; Paschalis-Thomas, D.; Ischiropoulous, H.; Kreindler, J.L.; Reed, D.R.; Cohen, N.A. (2012) T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. Journal of Clinical Investigation, 122, 4145-4159.
Knaapila, A.; Zhu, G.; Medland, S.E.; Wysocki, C.J.; Montgomery, G.W.; Martin, N.G.; Wright, M.J.; Reed, D.R. (2012) A genome-wide study on the perception of the odorants androstenone and galaxolide. Chemical Senses, 37, 541-552.
Knaapila, A.; Hwang, L.D.; Lysenko, A.; Duke, F.F.; Fesi, B.; Khoshnevisan, A.; James, R.S.; Wysocki, C.J.; Rhyu, M.; Tordoff, M.G.; BAchmanov, A.A.; Mura, E.; Nagai, H.; Reed, D.R. (2012) Genetic analysis of chemosensory traits in human twins. Chemical Senses, 37, 869-881.
Jiang, P.; Li, X.; Glaser, D.; Li, W.; Brand, J.G.; Margolskee, R.F.; Reed, D.R.; Beauchamp, G.K. (2012) Major taste loss in carnivorous mammals. Proceedings of the National Academy of Science, USA, 109, 4956-4961.
Heitmann, B.L.; Westerterp, K.R.; Loos, R.J.; Sorensen, T.I.; O’Dea, K.; McLean, P.; Jensen, T.K.; Eisenmann, J.; Speakman, J.R.; Simpson, S.J.; Reed, D.R.; Westerterp-Plantenga, M.S. (2012) Obesity: lessons from evolution and the environment. Obesity Reviews, 13, 910-922.
Reed, D.R.; Duke, F.F.; Ellis, H.K.; Rosazza, M.R.; Lawler, M.P.; Alarcon, L.K.; Tordoff, M.G. (2011) Body fat distribution and organ weights of 14 common strains and a 22-strain consomic panel of rats. Physiology & Behavior, 103, 523-429.
Lipchock, S.V.; Reed, D.R.; Mennella, J.A. (2011) The gustatory and olfactory systems during infancy: implications for development of feeding behaviors in the high-risk neonate. Clinics in Perinatology, 38, 627-641.
Li, X.; Bachmanov, A.A.; Maehashi, K.; Li, W.; Lim, R.; Brand, J.G.; Thai, C.; Floriano, W.B.; Reed, D.R. (2011) Sweet receptor gene variation and aspartame blindness in primates and other species. Chemical Senses, 36, 453-475.
Reed, D.R.; Zhu, G.; Breslin, P.A.; Duke, F.F.; Henders, A.K.; Campbell, M.J.; Montgomery, G.W.; Medland, S.E.; Martin, N.G.; Wright, M.J. (2010) The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Human Molecular Genetics, 19, 4278-4285.
Reed, D.R.; Knaapila, A. (2010) Genetics of taste and smell: poisons and pleasures. Progress in Molecular Biology & Transitional Science, 94, 213-240.
Reed, D.R. (2010) Heritable variation in fat preference. In: J.P. Montmayeur & J. de Coutre (Eds.) Fat detection: taste, texture, and post-investive effects. Boca Raton: CRC Press, Taylor & Francis Group, 395-416.
Pelchat, M.L.; Bykowski, C.; Duke, F.F.; Reed, D.R. (2010) Excretion and perception of a characteristic odor in urine after asparagus ingestion: a psychophysical and genetic study. Chemical Senses, 36, 9-17.
Mennella, J.A.; Pepino, M.Y.; Duke, F.F.; Reed, D.R. (2010) Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genetics, 11, 60.
Mennella, J.A.; Pepino, M.Y.; Duke, F.F.; Reed, D.R. (2010) Psychophysical dissection of genotype effects on human bitter perception. Chemical Senses, 36, 161-167.
Cailu Lin, Research Associate (with Alexander Bachmanov)
Paule V. Joseph, RN & MSN, Graduate student, School of Nursing (co-mentored with Charlene Compher)
Corrine Mansfield, Lab Manager
Brad Fesi, Research Technician
Deborah Lee, Research Technician
Michael Marquis, Research Technician (starting Dec 10th 2012)
Anna Lysenko, Graduate student, Drexel University
Rebecca S. James, Undergraduate, University of Pennsylvania
Mary Xia, Undergraduate, University of Pennsylvania
Wendy Yu, Masters student, University of Pennsylvania
Gabriel Galson, Library
Past Reed Lab Members
Anna Lysenko, Lab manager – Graduate student at Drexel University
Daniel Hwang, Research technician – Graduate student at the University of Washington
Antti Knaapila, Postdoctoral researcher – Postdoctoral Researcher at University of Turku
Amin Khoshnevisan, Research technician – Western University of Health Sciences, Dental School
Fujiko Duke, Lab manager Broad Institute – Research technician for Matthew Meyerson
Amanda McDaniel, Research technician – R & D Scientist at Genisphere
Kirsten Mascioli, Research technician – Graduate Student at Thomas Jefferson University
Ke Lu, Research technician – Researcher at Brigham and Women’s Hospital
Zhenyu Chen, Research technician – unknown – get in touch!
Rameen Starling-Roney, Student – Howard University College of Medicine, MD
Murtaza Shakir, Student – Aga Khan Medical School
Macrina Cooper-White, High school student – Yale University
Abigal Bosk, High school student – Wheaton College
Minna Bak, High school student – University of Pennsylvania
Sarah Obenrader, High school student – Davidson College
Brian Gantick, Research technician – Web designer
Mauricio Avigdor, Research technician – Novartis Institutes for BioMedical Research
Laurie Pippett, Research technician – Senior Administrative Assistant at Kelly Services
Class of 2012
Tiffany Weiss Aleman
Class of 2011
Class of 2010
Brian R. Gantick
Class of 2009