Contact Information

(267) 519-4915
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Danielle Reed

Affiliations

Associate Director, Monell Chemical Senses Center
Member, Monell Chemical Senses Center

Education

Ph.D., Psychology; Yale University

Research Summary

We do studies to understand the exact relationship between genotype and phenotype in both animal models and in human subjects including twins. Phenotypes of interest include taste perception, food preferences and obesity.

Detailed description of research program

Keywords

sweet, genetics, taste, smell, obesity, genomics, genetic mapping

Recent Publications

Preprint:
Lin C, Fesi BD, Marquis M, Bosak NP, Lysenko A, Koshnevisan MA, Duke FF, Theodorides ML, Nelson TM, McDaniel AH, Avigdor M, Arayata CJ, Shaw L, Bachmanov AA, Reed DR. Burly1 is a mouse QTL for lean body mass that maps to a 0.8-Mb region on chromosome 2. bioRxiv 231647; doi: https://doi.org/10.1101/231647

Published:
Guo Y, Hwang LD, Li J, Eades J, Yu CW, Mansfield C, Burdick-Will A, Chang X, Chen Y, Duke FF, Zhang J, Fakharzadeh S, Fennessey P, Keating BJ, Jiang H, Hakonarson H, Reed DR, Preti G. Genetic analysis of impaired trimethylamine metabolism using whole exome sequencing. BMC Med Genet. 2017 Feb 15;18(1):11. doi: 10.1186/s12881-017-0369-8. PubMed PMID: 28196478; PubMed Central PMCID: PMC5310055.

Hariri BM, McMahon DB, Chen B, Freund JR, Mansfield CJ, Doghramji LJ, Adappa ND, Palmer JN, Kennedy DW, Reed DR, Jiang P, Lee RJ. Flavones modulate respiratory epithelial innate immunity: Anti-inflammatory effects and activation of the T2R14 receptor. J Biol Chem. 2017 May 19;292(20):8484-8497. doi: 10.1074/jbc.M116.771949. Epub 2017 Apr 3. PubMed PMID: 28373278; PubMed Central PMCID: PMC5437252.

Lin C, Fesi BD, Marquis M, Bosak NP, Lysenko A, Koshnevisan MA, Duke FF, Theodorides ML, Nelson TM, McDaniel AH, Avigdor M, Arayata CJ, Shaw L, Bachmanov AA, Reed DR. Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains. PLoS One. 2017 Dec 1;12(12):e0188972. doi: 10.1371/journal.pone.0188972. eCollection 2017. PubMed PMID: 29194435; PubMed Central PMCID: PMC5711020.

Lipchock SV, Spielman AI, Mennella JA, Mansfield CJ, Hwang LD, Douglas JE, Reed DR. Caffeine Bitterness is Related to Daily Caffeine Intake and Bitter Receptor mRNA Abundance in Human Taste Tissue. Perception. 2017 Mar-Apr;46(3-4):245-256. doi: 10.1177/0301006616686098. Epub 2017 Jan 24. PubMed PMID: 28118781.

Workman AD, Brooks SG, Kohanski MA, Blasetti MT, Cowart BJ, Mansfield C, Kennedy DW, Palmer JN, Adappa ND, Reed DR, Cohen NA. Bitter and sweet taste tests are reflective of disease status in chronic rhinosinusitis. J Allergy Clin Immunol Pract. 2017 Oct 17. pii: S2213-2198(17)30739-0. doi: 10.1016/j.jaip.2017.09.014. [Epub ahead of print] PubMed PMID: 29054707.

Lab Staff

Cailu Lin, Ph.D., Research Associate
Lauren Colquitt, B.S., Lab Manager
Alissa Nolden, Ph.D., Postdoctoral Fellow
Lauren Shaw, M.S., Graduate Student, University of Pennsylvania
Ivy Maina, B.S., University of Pennsylvania medical student (with Noam Cohen)
Joseph Whip, B.S., Research Assistant
David Li, Student intern

Past Reed Lab Members

Yasmine Boukataya, University of Pennsylvania undergraduate
Juyun Lim, sabbatical at Monell, Oregon State University
Corrine Mansfield, SUNY, Oswego, Masters of Education
Jennifer Douglas, Penn Otolaryngology resident
Natalia Bosak
Charles J. Arayata, Research technician, Mainland lab
Amanda McKnight
Brad Fesi
Gladys Tea – University of Pennsylvania undergraduate
Kellen Wartnow – University of Pennsylvania undergraduate
Emily Evans – graduate of Washington College
Molly Stein – University of Pennsylvania undergraduate
Wendy Yu – Data science, New York
Gabriel Galson, Library – Bibliographic Assistant II, Temple University
Paule V. Joseph, Graduate student – NIH postdoc in Wendy Henderson’s lab
Sarah V. Lipchock – Guston School
Deborah Lee, Research technician – medical school
Michael Marquis, Research technician – Harvard College, PhD in Neuroscience
Rebecca S. James, Student – Sunlight Foundation in Washington DC
Mary Xia, Student – Yahoo in metro San Francisco
Anna Lysenko, Lab manager – clinical laboratory in metro DC area
Daniel Hwang, Research technician – Graduate student at University of Queensland
Antti Knaapila, Postdoctoral researcher – Postdoctoral Researcher at University of Turku
Amin Khoshnevisan, Research technician – Oral and Maxillofacial residency, St. Joseph’s Regional Medical Center, NJ
Fujiko Duke, Lab manager Broad Institute – Matthew Meyerson lab
Amanda McDaniel, Research technician – BioElectroMed
Kirsten Mascioli, Research technician – Technical Specialist III at The Children’s Hospital of Philadelphia
Ke Lu, Research technician – Brigham and Women’s Hospital
Zhenyu Chen, Research technician – location unknown, Zhenyu please get in touch!
Rameen Starling-Roney, Student – Howard University College of Medicine, MD
Murtaza Shakir, Student – Aga Khan Medical School
Macrina Cooper-White, High school student – Yale University
Abigal Bosk, High school student – Wheaton College
Minna Bak, High school student – University of Pennsylvania
Sarah Obenrader, High school student – Davidson College
Brian Gantick, Research technician – Web designer
Mauricio Avigdor, Research technician – Novartis Institutes for BioMedical Research
Laurie Pippett, Research technician – Senior Administrative Assistant at Kelly Services

Twinsburg Alumni

Class of 2017

CJ Arayata
Nuala Bobowski
Lauren Colquitt
Fujiko Duke
Hillary Ellis
Brad Fesi
Federica Genovese
Nicole Greenbaum
Alex Mangroo
Corrine Mansfield
Michael Marquis
Alissa Nolden
Lauren Shaw
Casey Trimmer

Class of 2016

CJ Arayata
Nuala Bobowski
Jennifer Douglas
Hillary Ellis
Brad Fesi
Marie Knoll
Alex Mangroo
Corrine Mansfield
Michael Marquis
Elliott McDowell
Lauren Shaw
Jake Saunders
Alyssa Treff
Casey Trimmer

Class of 2015

Kelsey Alderman
CJ Arayata
Nuala Bobowski
Laurel Doghramji
Jennifer Douglas
Hilary Ellis
Brad Fesi
Nicole Greenbaum
Rebecca James
John Lees
Alex Mangroo
Corrine Mansfield
Michael Marquis
Lauren Shaw
Casey Trimmer

Class of 2014

Seth Brockman
Fujiko Duke
Emily Evans
Brad Fesi
Rebecca James
Daniel Lee
Deborah Lee
Anna Lysenko
Alex Mangroo
Corrine Mansfield
Michael Marquis
Kevin Redding
Molly Stein
Ana Ulloa

Class of 2013

Seth Brockman
Fujiko Duke
Brad Fesi
Rebecca James
Daniel Lee
Deborah Lee
Anna Lysenko
Alex Mangroo
Corrine Mansfield
Michael Marquis
Kevin Redding

Class of 2012

Tiffany Weiss Aleman
Seth Brockman
Fujiko Duke
Brad Fesi
Daniel Hwang
Anna Lysenko
Alex Mangroo
Kevin Redding

Class of 2011

Seth Brockman
Danielle Crawford
Fujiko Duke
Daniel Hwang
Matt Kirkey
Anna Lysenko
Kevin Redding

Class of 2010

Laura Alarcon
Calvin Alarcon
Fujiko Duke
Brian R. Gantick
Matt Kirkey
Antti Knaapila
Amin Koshnevisan
Michelle Murphy
Tom Uleau

Class of 2009

Laura Alarcon
Fujiko Duke
Brian Gantick
Ryan McDermott