Contact Information

(267) 519-4794
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Dolly Al Koborssy

Affiliations

Postdoctoral Fellow, Monell Chemical Senses Center

Laboratory of

Dr. Johannes Reisert

Education

Ph.D., Neuroscience, Florida State University

Research Summary

I’m interested in studying olfaction at the level of the olfactory epithelium. Binding of an odorant molecule to its receptor triggers a signaling cascade in the olfactory epithelium involving different secondary messenger molecules and ion channels. We don’t know, however, the exact contribution of each component of the olfactory signaling transduction to olfactory perception. To answer this question, I’m using single-cell electrophysiology on olfactory receptor neurons to understand how the olfactory nerve signal is generated in response to specific odorants, how the olfactory response is terminated, and the details of the mechanism underlying olfactory adaptation.

Keywords

Olfaction, single-cell electrophysiology, ion channels, transduction

Recent Publications

Al Koborssy D., Palouzier-Paulignan B., Canova V., Thevenet M., Fadool D.A., Julliard A.K. (2018). Modulation of olfactory-driven behavior by metabolic signals: Role of the piriform cortex. Brain Struct Funct. PMID: 30317390.

Julliard A.K., Al Koborssy D., Fadool D.A., Palouzier-Paulignan B. (2016). Nutrient sensing: another chemosensitivity of the olfactory system. Front. Physiol. 8(468). PMID: 28747887.

Al Koborssy D., Palouzier-Paulignan B., Salem R., Thevenet M., Romestaing C., Julliard A.K. (2014). Cellular and molecular cues of glucose sensing in the rat olfactory bulb. Front. Neurosci. 8(333). PMID: 25400540