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(267) 519-4778
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Ichiro Matsumoto


Associate Member, Monell Chemical Senses Center


Ph.D., Molecular Biology; University of Tokyo

Research Summary

My primary research interest is the coding mechanism of taste modality, specifically whether gustatory neurons are heterogeneous or homogeneous. Also, I am interested in the turnover of taste receptor cells and establishment and maintenance of peripheral gustatory wiring between taste receptor cells and gustatory neurons.


Taste, Development, Differentiation, Diversity, Evolution

Recent Publications

Lei,W., Ren,W., Ohmoto,M., Urban,J.F., Jr., Matsumoto,I., Margolskee,R.F., and Jiang,P. (2018). Activation of intestinal tuft cell-expressed Sucnr1 triggers type 2 immunity in the mouse small intestine. Proc. Natl. Acad. Sci. U. S. A. 115, 5552-5557.

Ma,Z., Taruno,A., Ohmoto,M., Jyotaki,M., Lim,J.C., Miyazaki,H., Niisato,N., Marunaka,Y., Lee,R.J., Hoff,H., Payne,R., Demuro,A., Parker,I., Mitchell,C.H., Henao-Mejia,J., Tanis,J.E., Matsumoto,I., Tordoff,M.G., and Foskett,J.K. (2018). CALHM3 Is essential for rapid ion channel-mediated purinergic neurotransmission of GPCR-mediated tastes. Neuron 98, 547-561.

Lemons,K., Fu,Z., Aoude,I., Ogura,T., Sun,J., Chang,J., Mbonu,K., Matsumoto,I., Arakawa,H., and Lin,W. (2017). Lack of TRPM5-expressing microvillous cells in mouse main olfactory epithelium leads to impaired odor-evoked responses and olfactory-guided behavior in a challenging chemical environment. eNeuro. 4, ENEURO.0135-17.2017.

Ohmoto,M., Ren,W., Nishiguchi,Y., Hirota,J., Jiang,P., and Matsumoto,I. (2017). Genetic lineage tracing in taste tissues using Sox2-CreERT2 strain. Chem. Senses 42, 547-552.

Yamashita,J., Ohmoto,M., Yamaguchi,T., Matsumoto,I., and Hirota,J. (2017). Skn-1a/Pou2f3 functions as a master regulator to generate Trpm5-expressing chemosensory cells in mice. PLoS One 12, e0189340.

Gerbe,F., Sidot,E., Smyth,D.J., Ohmoto,M., Matsumoto,I., Dardalhon,V., Cesses,P., Gatnier,L., Pouzolles,M., Brulin,B., Bruschi,M., Harcus,Y., Zimmermann,V.S., Taylor,N., Maizel,R.M., and Jay,P. (2016). Intestinal epithelial tuft cells initiate type 2 mucosal immunity helminth parasites. Nature 529, 226-230.

Meada,N., Ohmoto,M., Yamamoto,K., Kurokawa,A., Narukawa,M., Ishimaru,Y., Misaka,T., Matsumoto,I., and Abe,K. (2016). Expression of serotonin receptor genes in cranial ganglia. Neuroscience Letters 617, 46-51.

Nishiguchi,Y., Ohmoto,M., Koki,J., Enomoto,T., Kominami,R., Matsumoto,I., and Hirota,J. (2016). Bcl11b/Ctip2 is required for development of lingual papillae in mice. Developmental Biology 416, 98-110.

Vingtdeux, V, Chang, E. H, Frattini, S. A., Zhao, H., Chandakkr, P., Adrien, L., Strohl, J. J., Gibson, E. L., Ohmoto, M., Matsumoto, I., Huerta, P. T., and Marambaud, P. CALHM1 deficiency impairs cerebral neuron activity and memory flexibility in mice. Scientific Reports 6, e24250. 2016.

Tordoff,M.G., Aleman,T.R., Ellis,H.T., Ohmoto,M.,Matsumoto,I., Shestopalov,V.I., Mitchell,C.H., Foskett,J.K., and Poole,R.L. (2015). Normal taste acceptance and preference of PANX1 knockout mice. Chemical Senses 40, 453-459.

Yamaguchi, T.; Yamashita, J.; Ohmoto, M.; Aoudé, I.; Ogura, T.; Luo, W.; Bachmanov, A. A.; Lin, W.; Matsumoto, I.; Hirota, J. (2014) Skn-1a/Pou2f3 is required for the generation of Trpm5-expressing microvillus cells in the mouse main olfactory epithelium. BMC Neuroscience, 15, 13.

Bachmanov, A.A.; Bosak, N.P.; Lin, C.; Matsumoto, I.; Ohmoto, M.; Reed, D.R.; Nelson, T.M. (2013) Genetics of taste receptors. Current Pharmaceutical Design, (Electronic citation) PMID: 23886383

Matsumoto, I.; Ohmoto, M.; Abe, K. (2013) Functional diversification of taste cells in vertebrates. Seminars in Cell & Developmental Biology, 24, 210-214.

Matsumoto, I.(2013) Gustatory neural pathways from taste receptor cells revealed by genetic tracing. Bioscience, Biotechnology, Biochemisty, 77, 1359-1362.

Ohmoto, M.; Yamaguchi, T.; Yamashita, J.; Bachmanov, A.A.; Hirota, J.; Matsumoto, I. (2013) Pou2f3/Skn-1a is necessary for the generation or differentiation of solitary chemosensory cells in the anterior nasal cavity. Bioscience, Biotechnology, Biochemisty, 77, 2154-2156.

Taruno, A.; Matsumoto, I.; Ma, Z.; Marambaud, P.; Foskett, J.K. (2013) CALHM1: An ion channel mediator of neurotransmission from taste cells devoid of synapses. BioEssays, 35, 1111-1118.

Taruno, A.; Vingtdeux, V.; Ohmoto, M.; Ma, Z.; Dvoryanchikov, G.; Li, A.; Adrian, L.; Zhao, H.; Leung, S.; Abernethy, M.; Koppel, J.; Davies, P.; Civan, M.M.; Chaudhari, N.; Matsumoto, I.; et al. (2013) CALHM1 ion channel mediates purinergic neurotransmission of sweet, bitter and umami tastes. Nature, 495, 223-226.

Yamamoto, K.; Ishimaru, Y.; Ohmoto, M.; Matsumoto, I.; Asakura, T.; Abe, K. (2011) Genetic tracing of the gustatory neural pathways originating from PKD1L3-expressing type III taste cells in circumvallate and foliate papillae. Journal of Neurochemistry, 119, 497-506.

Enomoto, T.; Ohmoto, M.; Iwata, T.; Uno, A.; Saitou, M.; Yamaguchi, T.; Kominami, R.; Matsumoto, I..; Hirota, J. (2011) Bcl11b/Ctip2 controls the differentiation of vomeronasal sensory neurons in mice. Journal of Neuroscience, 31, 10159-10173.

Matsumoto, I.; Ohmoto, M.; Narukawa, M.; Yoshihara, Y.; Abe, K. (2011) Skn-1a/Pou2f3 specifies taste receptor cell lineage. Nature Neuroscience, 14, 685-687.

Ohmoto, M.; Okada, S.; Nakamura, S.; Abe, K.; Matsumoto, I. (2011) Mutually exclusive expression of Gaia and Ga14 reveals diversification of taste receptor cells in zebrafish. Journal of Comparative Neurology, 519, 1616-1629.

Matsumoto, I. (2011) Cell fate specification to sweet, umami, and bitter taste receptor cells by Skn-1a. Experimental Medicine, 29, 2661-2664.

Matsumoto, I. (2009) Genetic tracing of gustatory neural pathway. Japanese Journal of Taste and Smell Research, 16, 125-131.

Yamashita, H.; Nakagawa, K.; Hosoi, Y.; Kurokawa, A.; Fukuda, Y.; Matsumoto, I.; Misaka, T.; Abe, K. (2009) Umami taste dysfunction in patients receiving radiotherapy for head and neck cancer. Oral Oncology, 45, e19-23.

Matsumoto, I.; Ohmoto, M.; Yasuoka, A.; Yoshihara, Y.; Abe, K. (2009) Genetic tracing of the gustatory neural pathway originating from T1R3-expressing sweet/umami taste receptor cells. Annals of the New York Academy of Sciences, 1170, 46-50.

Ohmoto, M.; Matsumoto, I.; Yasuoka, A.; Yoshihara, Y.; Abe, K. (2008) Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells. Molecular and Cellular Neuroscience, 38, 505-517.