PhD, Molecular Biology; Yale University
My research is directed at the molecular mechanisms that underlie taste sensation and food preference. The focus is on identifying molecules that are involved in the recognition and transmission of taste stimuli in the oral cavity and other parts of the digestive system. This work has implications for understanding the cellular and molecular basis of gustatory perception, which may lead to effective treatments of taste disorders.
single cells, gene expression, signal transduction, taste perception, digestive system
Xu, J.; Cao, J.; Iguchi, N.; Riethmacher, D.;Huang, L. (2013) Functional characterization of bitter taste receptors expressed in mammalian testis. Molecular Human Reproduction, 19, 17-28.
Du, L.; Wu, C.; Peng, H.; Zhao, L.; Huang, L.; Wang, P. (2013) Bioengineered olfactory sensory neuron-based biosensor for specific odorant detection. Biosensors and Bioelectronics, 40, 401-406.
Feng, P.; Zhao, H.; Chai, J.; Huang, L.; Wang, H. (2012) Expression and secretion of TNF-a in mouse taste buds: a novel function of a specific subset of type II taste cells. PLoS ONE, 7, e43140.
Kim, A.; Feng, P.; Ohkuri, T.; Sauers, D.; Cohn, Z.J.; Chai, J.; Nelson, T.; Bachmanov, A.A.; Huang, L.; Wang, H. (2012) Defects in the peripheral taste structure and function in the MRL/lpr mouse model of autoimmune disease. PLoS ONE, 7, e35588.
Iguchi N.; Ohkuri, T.; Slack, J. P.; Zhong, P. and Huang, L. (2011) Sarco/endoplasmic reticulum ca2+-atpases (SERCA) contribute to gpcr-mediated taste perception. PLoS ONE, 6, e23165.
Cohn, Z. J.; Kim, A.; Huang, L.; Brand, J. and Wang, H. (2010) Lipopolysaccharide-induced inflammation attenuates taste progenitor cell proliferation and shortens the life span of taste bud cells. BMC Neuroscience, 11, 72.
Hunter-Smith, S. and Huang, L. (2009) Human taste: peripheral anatomy, taste transduction and coding. AgroFood Industry Hi-Tech, 20, 24-27.
Maehashi, K. and Huang, L. (2009) Bitter peptides and bitter taste receptors. Cellular and Molecular Life Sciences, 66, 1661-1671.
Rawson, N. E. and Huang, L. (2009) Symposium overview: Impact of oronasal inflammation on taste and smell. Annals of the New York Academy of Sciences, 1170, 581-584.
Wang, H.; Iguchi, N.; Rong, Q.; Zhou, M.; Ogukunorode, M.; Inoue, M.; Pribitkin, E. A.; Bachmanov, A. A.; Margolskee, R. F.; Pfeifer, K. and Huang, L. (2009) Expression of the voltage-gated potassium channel KCNQ1 in mammalian taste bud cells and the effect of its null-mutation on taste preferences. Journal of Comparative Neurology, 512, 384-398.
Wang, H.; Zhou, M.; Brand, J. and Huang, L. (2009) Inflammation and taste disorders: mechanisms in taste buds. Annals of the New York Academy of Sciences, 1170, 596-603.
Huang, L. (2008) Bitter taste for flavor and health. Perfumer and Flavorist, 33, 52-55.
Naim, M; Shaul, M. E.; Spielman, A. I.; Huang, L. and Peri, I. (2008) Permeation of amphipathic sweeteners into taste-bud cells and their interactions with post-receptor signaling components: Possible implications for sweet-taste quality. In: Weearsinghe, D.K.; Dubois, G. (Ed.s) Sweetness and Sweeteners: Biology, Chemistry, and Psychophysics. London: Oxford University Press, 241-255.
Maehashi, K.; Matano, M.; Wang, H.; Vo, L.A.; Yamamoto, Y.; Huang, L. (2008) Bitter peptides activate hTAS2Rs, the human bitter receptors. Biochemical and Biophysical Research Communications, 365, 851-855.
Wang, H.; Zhou, M.; Brand, J.; Huang, L. (2007) Inflammation activates the interferon signaling pathways in taste bud cells. Journal of Neuroscience, 27, 10703-10713.
Breslin, P.A.S.; Huang, L. (2006) Human taste: peripheral anatomy, taste transduction and coding. Advances in Otorhinolaryngology, 63, 152-190.
Huang, L.; Cao, J.; Wang, H.; Vo, L.A.; Brand, J.G. (2005) Identification and functional characterization of a voltage-gated chloride channel and its novel splice variant in taste bud cells. Journal of Biological Chemistry, 280, 36150-36157.