Contact Information

(267) 519-4824
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M. Hakan Ozdener

Affiliations

Research Associate, Monell Chemical Senses Center

Education

M.D., Ondokuz Mayis University, Samsun, Turkey
Ph.D., Biochemistry; Ondokuz Mayis University, Samsun Turkey, -ICGEB, New Delhi India
MPH, (Public Health); Temple University

Research Summary

My primary research focuses on the development of in vitro chemosensory cell culture systems for the study of chemosensory biology and disorders. I utilize chemosensory cells obtained from human and from rodent to examine the factors involved in differentiation and maturation and to better understand how chemosensory receptor cells interact in their responses to stimuli. This work will enable us to develop and characterize novel tastent and new therapeutic targets to promote regeneration following injury from surgery, radiation, toxic exposures or deterioration due to aging or neurodegenerative disease.

Keywords

taste cell, olfactory cells, development, cell culture, chemosensory cells and infection

Recent Publications

Ozdener, M.H.; Subramaniam, S.; Sundaresan, S.; Sery, O.; et al. (2014) CD36- and GPR120-Mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Gastroenterology. (Electronic citation) doi: 10.1053/j.gastro.2014.01.006

Ozdener, M.H.; Rawson, N.E. (2013) Primary culture of mammalian taste epithelium. Methods in Molecular Biology, 945, 95-107.

Rawson, N.E.; Ozdener, M.H. (2013) Primary culture of the human olfactory neuroepithelium. Methods in Molecular Biology, 945, 81-93.

Kwak, J.; Gallagher, M.; Ozdener, M.H.; Wysocki, C.J.; Goldsmith, B.R.; Isamah, A.; Faranda, A.; Fakharzadeh, S.S.; Herlyn, M.; Johnson, A.T.; Preti, G. (2013) Volatile biomarkers from human melanoma cells. , 931, 90-96.

Ozdener, M.H.; Spielman, A.I.; Rawson, N.E. (2012) Isolation and culture of human fungiform taste papillae cells. Journal of Visual Experiments, 63, e3730.

Ozdener, M.H.; Rawson, N.E. (2012) Exogenous EGF and BDNF treatment triggered cultured taste cell differentiation and proliferation. Turkish Journal Medical Sciences, 42, 1-14.

Ozdener, M.H.; Rawson, N.E. (2011) Culture and maintenance of taste cells in vitro. In Vitro Cellular & Developmental Biology – Animal, 47, 513-514.

Ozdener, M.H.; Brand, J.G.; Spielman, A.; Lischka, F.W.; Teeter, J.H.; Breslin, P.; Rawson, N.E. (2011) Method for long term primary culture of human fungiform taste bud cells in culture. Chemical Senses, 36, 601-612.

Jaén, C.; Ozdener, M.H., Reisert, J. (2011) Mechanisms of chloride uptake in frog olfactory receptor neurons. Journal of Comparative Physiology A, Neuroethology, Sensory, Neural, & Behavioral Physiology, 197, 339-349.

Mandel, A.L.; Ozdener, M.H.; Utermohlen, V. (2011) Brain-derived neurotrophic factor in human saliva: ELISA optimization and biological correlates. Journal of Immunoassay & Immunochemistry, 32, 18-30.

Dalton, P.H.; Opiekun, R.E.; Wilson, T.; Maute, C.; Ozdener, M.H.; Zhao, K.; Emmet, E.; Lees, P.; Herbert, R.; Moline, J. (2010) Chemosensory loss: Functional consequences of the world trade center disaster. Environmental Health Perspectives, 118, 1251-1256.

Ozdener, M.H.; Yee, K.K.; McDermott, R.; Cowart, B.J.; Vainius, A.A.; Dalton, P.; Rawson, N.E. (2009) Assessment of smoking status based on cotinine levels in nasal lavage fluid. Tobacco Induced Diseases, 3, 11.

Mandel, A.L.; Ozdener, M.H.; Utermohlen, V. (2009) Identification of pro- and mature brain-derived neurotrophic factor in human saliva. Archives of Oral Biology, 54, 689-695.

Borgmann-Winter, K.E.; Rawson, N.E.; Wang, H-Y.; Wang, H.; MacDonald, M.L.; Ozdener, M.H.; Yee, K.K.; Gomez, G.; Xu, J.; Bryant, B.; Adamek, G.; Mirza, N.; Pribitkin, E.; Hahn, C-G. (2009) Human olfactory epithelial cells generated in vitro differentiate to express a diversity of neuronal functions. Neuroscience, 158, 642-653.

Ozdener, M.H. (2007) Inducible functional expression of Bcl-2 in human astrocytes derived from NTera-2 cells. Journal of Neuroscience Methods, 159, 8-18.

Ozdener, M.H.; Yee, K.K.; Cao, J.; Brand, J.G.; Teeter, J.H.; Rawson, N.E. (2006) Characterization and long-term maintenance of rat taste cells in culture. Chemical Senses, 31, 279-290.

Ozdener, M.H.. (2005) Molecular mechanisms of HIV-1 associated neurodegeneration. Journal of Biosciences, 10, 101-115.

Ozdener, M.H.; Rawson, N.E. (2004) Olfactory dysfunction in neurodegenerative diseases. European Journal of General Medicine, 1, 1-11.