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M. Hakan Ozdener


Senior Research Associate, Monell Chemical Senses Center

Laboratory of

Dr. Robert Margolskee


M.D., Ondokuz Mayis University, Samsun, Turkey
Ph.D., Biochemistry; Ondokuz Mayis University, Samsun Turkey, -ICGEB, New Delhi India
MPH, (Public Health); Temple University

Research Summary

My primary research focuses on the development of in vitro chemosensory cell culture systems for the study of chemosensory biology and disorders. I utilize chemosensory cells obtained from human and from rodent to examine the factors involved in differentiation and maturation and to better understand how chemosensory receptor cells interact in their responses to stimuli. This work will enable us to develop and characterize novel tastent and new therapeutic targets to promote regeneration following injury from surgery, radiation, toxic exposures or deterioration due to aging or neurodegenerative disease.


taste cell, olfactory cells, development, cell culture, chemosensory cells and infection

Recent Publications

Ozdener, M.H.; Donadoni, M.; Cicalese, S.; Spielman, A.I.; Garcia-Blanco, A.; Gordon, J.; Sariyer, I.K. (2020) Zika virus infection in chemosensory cells. J Neurovirol. doi: 10.1007/s13365-020-00835-2. [Epub ahead of print]

Malik, B.; Elkaddi, N.; Turkistani, J.; Spielman, A.I.; Ozdener, M.H. (2019) Mammalian Taste Cells Express Functional Olfactory Receptors. Chemical Senses. 44, 289-301. doi: 10.1093/chemse/bjz019.

Murtaza, B.; Hichami, A.; Khan, A.S.; Shimpukade, B.; Ulven, T.; Ozdener, M.H.; Khan, N.A. (2019) Novel GPR120 agonist TUG891 modulates fat taste perception and preference and activates tongue-brain-gut axis in mice. Journal of Lipid Research. pii: jlr.RA119000142. doi: 10.1194/jlr.RA119000142.

Ozdener, M.H.; Ashby, R.D.; Jyotaki, M.; Elkaddi, N.; Spielman, A.I.; Bachmanov, A.A.; Solaiman, D.K. (2019) Sophorolipid Biosurfactants Activate Taste Receptor Type 1 Member 3ÔÇÉMediated Taste Responses and Block Responses to Bitter Taste In Vitro and In Vivo. Journal of Surfactants and Detergents. doi:10.1002/jsde.12246

Sariyer, I.K.; Gordon, J.; Burdo, T.H.; Wollebo, H.S.; Gianti, E.; Donadoni, M.; Bellizzi, A.; Cicalese, S.; Loomis, R.; Robinson, J.A.; Carnevale, V.; Steiner, J.; Ozdener, M.H.; Miller, A.D.; Amini, S.; Klein, M.L.; Khalili, K. (2019) Suppression of Zika Virus Infection in the Brain by the Antiretroviral Drug Rilpivirine. Molecular Therapy. doi: 10.1016/j.ymthe.2019.10.006.

Qian, J.; Mummalaneni, S.; Larsen, J.; Grider, J.R.; Spielman, A.I.; Ozdener M.H.; Lyall V. (2018) Nicotinic acetylcholine receptor (CHRN) expression and function in cultured human adult fungiform (HBO) taste cells. PLoS One. Mar 7;13(3):e0194089. doi: 10.1371/journal.pone.0194089.

Barbarossa, I.T.; Ozdener, M.H.; Melis, M.; Love-Gregory, L.; Mitreva, M.; Abumrad, N.A.; Pepino, M.Y. (2017) Variant in a common odorant-binding protein gene is associated with bitter sensitivity in people. Behavioural Brain Research, 329, 200-204. doi: 10.1016/j.bbr.2017.05.015

Borisevich, V.; Ozdener, M.H.; Malik, B.; Rockx, B. (2017) Hendra and Nipah Virus Infection in Cultured Human Olfactory Epithelial Cells. mSphere, 28;2(3). doi:10.1128/mSphere.00252-17

Murtaza, B.; Berrichi, M.; Bennamar, C.; Tordjmann, T.; Djeziri, F. Z.; Hichami, A.; Leemput, J.; Belarbi, M; Ozdener, M.H.; Khan, N.A. (2017) Zizyphin modulates calcium signalling in human taste bud cells and fat taste perception in the mouse. Fundamental & Clinical Pharmacology. doi: 10.1111/fcp.12289

Ozdener, M.H.; Spielman, A.I.; Rawson, N.E. (2017) Method for culture and maintenance of long term primary human fungiform taste cells. Nature Protocol Exchange. doi:10.1038/protex.2017.065

Qian, J.; Mummalaneni, S.; Phan, T.T.; Heck, G.L.; DeSimone, J.A.; West, D.; Mahavadi, S.; Hojati, D.; Murthy, K.S.; Rhyu, M.R.; Spielman, A.I.; Ozdener, M.H.; Lyall, V. (2017) Cyclic-AMP regulates postnatal development of neural and behavioral responses to NaCl in rats. PLoS One, 12, e0171335.

Xu, J.J.; Elkaddi, N.; Garcia-Blanco, A.; Spielman, A.I.; Bachmanov, A.A.; Chung, H.Y.; Ozdener, M.H.. (2017) Arginyl dipeptides increase the frequency of NaCl-elicited responses via epithelial sodium channel alpha and delta subunits in cultured human fungiform taste papilla cells. Scientific Reports, 7, 7483. doi:10.1038/s41598-017-07756-x

Subramaniam, S.; Ozdener, M.H.; Abdoul-Azize, S.; Saito, K., Malik, B.; et al. (2016) ERK1/2 activation in human taste bud cells regulates fatty acid signaling and gustatory perception of fat in mice and humans. FASEB J, 30, 3489-3500.

Ozdener, M.H.; Subramaniam, S.; Sundaresan, S.; Sery, O.; et al. (2014) CD36- and GPR120-Mediated Ca2+ signaling in human taste bud cells mediates differential responses to fatty acids and is altered in obese mice. Gastroenterology, 146, 995-1005.

Ozdener, M.H.; Rawson, N.E. (2013) Primary culture of mammalian taste epithelium. Methods in Molecular Biology, 945, 95-107.

Rawson, N.E.; Ozdener, M.H. (2013) Primary culture of the human olfactory neuroepithelium. Methods in Molecular Biology, 945, 81-93.

Kwak, J.; Gallagher, M.; Ozdener, M.H.; Wysocki, C.J.; Goldsmith, B.R.; Isamah, A.; Faranda, A.; Fakharzadeh, S.S.; Herlyn, M.; Johnson, A.T.; Preti, G. (2013) Volatile biomarkers from human melanoma cells. Journal of Chromatography B, 931, 90-96.

Ozdener, M.H.; Spielman, A.I.; Rawson, N.E. (2012) Isolation and culture of human fungiform taste papillae cells. Journal of Visual Experiments, 63, e3730.

Ozdener, M.H.; Rawson, N.E. (2012) Exogenous EGF and BDNF treatment triggered cultured taste cell differentiation and proliferation. Turkish Journal Medical Sciences, 42, 1-14.

Ozdener, M.H.; Rawson, N.E. (2011) Culture and maintenance of taste cells in vitro. In Vitro Cellular & Developmental Biology – Animal, 47, 513-514.

Ozdener, M.H.; Brand, J.G.; Spielman, A.; Lischka, F.W.; Teeter, J.H.; Breslin, P.; Rawson, N.E. (2011) Method for long term primary culture of human fungiform taste bud cells in culture. Chemical Senses, 36, 601-612.

Dalton, P.H.; Opiekun, R.E.; Wilson, T.; Maute, C.; Ozdener, M.H.; Zhao, K.; Emmet, E.; Lees, P.; Herbert, R.; Moline, J. (2010) Chemosensory loss: Functional consequences of the world trade center disaster. Environmental Health Perspectives, 118, 1251-1256.