Robert Margolskee

Associate Director & Member

Education

M.D., Ph.D., Molecular Genetics; Johns Hopkins University

Research Summary

Dr. Margolskee’s long-standing research focus is on the molecular mechanisms of taste transduction, utilizing molecular biology, biochemistry, structural biology, electrophysiology and transgenesis to study the mechanisms of signal transduction in mammalian taste cells. More recently he has been studying the chemosensory functions of taste signaling proteins in gut and pancreatic endocrine cells. Other project in the Margolskee lab are taste stem cells and endocrine properties of taste cells.

Keywords

taste receptor, molecular biology, gastrointestinal chemosensation, transduction, taste signalling proteins, endocrine function, stem cells

Recent Publications

Yee, K.K.; Li, Y.; Redding, K.M.; Iwatsuki, K.; Margolskee, R.F.; Jiang, P. (2013) Lgr5-EGFP Marks Taste Bud Stem/Progenitor Cells in Posterior Tongue. Stem Cells. doi:10.1002/stem.1338.

Li, Y.; Kokrashvili, Z.; Mosinger, B.; Margolskee, R.F. (2013) Gustducin couples fatty acid receptors to GLP-1 release in colon. American Journal of Physiology, Endocrinology and Metabolism. doi: 10.1152/ajpendo.00471.2012

Glendinning, J.I.; Gillman, J.; Zamer, H.; Margolskee, R.F.; Sclafani, A. (2012) The role of T1r3 and Trpm5 in carbohydrate-induced obesity in mice. Physiology and Behavior, 107, 50-58.

Yee, K.K.; Sukumaran, S.K.; Kotha, R.; Gilbertson, T.A.; Margolskee, R.F. (2011) Glucose transporters and atp-gated k+ (katp) metabolic sensors are present in type 1 taste receptor 3 (t1r3)-expressing taste cells. Proceedings of the National Academy of Sciences USA, 108, 5431-5436.

Ilegems, E.; Iwatsuki, K.; Kokrashvili, Z.; Outhiriaradjou, B.; Ninomiya, Y.; Margolskee, R.F. (2010) REEP2 enhances sweet receptor function by recruitment to lipid rafts. Journal of Neuroscience, 30, 13774-13783.

Murata, Y.; Yasuo, T.; Yoshida, R.; Obata, K.; Yanagawa, Y.; Margolskee, R.F.; Ninomiya, Y. (2010) Action potential-enhanced ATP release from taste cells through hemichannels. Neurophysiology, 104, 896-901.

Reed, D.R.;Margolskee, R.F. (2010) Gustation genetics: Sweet gustducin! Chemical Senses, 35, 549-550.

Yoshida, R.; Okhuri, T.; Jyotaki, M.; Yasuo, T.; Horio, N.; Yasumatsu, K.; Sanematsu, K.; Shigemura, N.; Yanamato, T.; Margolskee, R.F.; Ninomiya, Y. (2010) Endocannabinoids selectively enhance sweet taste.”Proceedings of the National Academy of Sciences USA, 107, 935-939.

Kokrashvili, Z.; Mosinger, B.; Margolskee, R.F. (2009) Taste signaling elements expressed in gut enteroendocrine cells regulate nutrient-responsive secretion of gut hormones.American Journal of Clinical Nutrition, 90.3, 822S-5S.

Kokrashvili, Z.; Rodriguez, D.; Yevshayeva, V.; Zhou, H.; Margolskee, R.F.; Mosinger, B. (2009) Release of endogenous opioids from duodenal enteroendocrine cells requires Trpm5.Gastroenterology, 137.2, 598-606.

Maillet, E.L.; Margolskee, R.F., Mosinger, B. (2009) Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3. Journal of Medicinal Chemistry, 12, 6931-35.