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Mark Friedman


Member Emeritus, Monell Chemical Senses Center


Ph.D., Physiological Psychology; Princeton University

Research Summary

My research is directed at the bodily mechanisms that control eating behavior. The focus is on identifying those changes in energy metabolism that serve as signals controlling food intake and characterizing how these signals are detected and transmitted to the brain. This work has implications for understanding the behavioral contribution to energy balance and for treating disturbances in food intake and appetite.


appetite, energy metabolism, liver, obesity, feeding behavior

Recent Publications

Horn, C.C.; Still, L.; Fitzgerald, C; Friedman, M.I. (2010) Food restriction, refeeding, and gastric fill fail to affect emesis in musk shrews. American Journal of Physiology, 298, G25-30.

Ji, H.; Friedman, M.I. (2008) Reduced hepatocyte fatty acid oxidation in outbred rats pre-screened for susceptibility to diet-induced obesity. International Journal of Obesity, 32, 1331-1334.

Friedman, M.I. (2008) Food intake: Control, regulation and the illusion of dysregulation. In: Harris, R.; Mattes, R. (Eds) Appetite and Food Intake: Behavioral and Physiological Considerations, Boca Raton: CRC Press, 1-19.

Friedman, M.I. (2007) Obesity and the hepatic control of feeding behavior. Drug News & Perspectives, 20, 573-578.

Ji, H.; Friedman, M.I. (2007) Reduced capacity for fatty acid oxidation in rats with inherited susceptibility to diet-induced obesity. Metabolism, 56, 1124-1130.

Ji, H.; Outterbridge, L.V.; Friedman, M.I. (2005) Phenotype-based treatment for dietary obesity: Differential effects of fenofibrate in obesity-prone and obesity-resistant rats. Metabolism, 54, 421-429.

Ji, H.; Friedman, M.I. (2003) Fasting plasma triglyceride levels and fat oxidation predict dietary obesity in rats. Physiology & Behavior, 78, 767-772.