Mark Friedman

Associate Director & Member

Education

Ph.D., Physiological Psychology, Princeton University

Research Summary

My research is directed at the bodily mechanisms that control eating behavior. The focus is on identifying those changes in energy metabolism that serve as signals controlling food intake and characterizing how these signals are detected and transmitted to the brain. This work has implications for understanding the behavioral contribution to energy balance and for treating disturbances in food intake and appetite.

Keywords

appetite, energy metabolism, liver, obesity, feeding behavior

Recent Publications

Ji, H. & Friedman, M. I. (2008). Reduced hepatocyte fatty acid oxidation in outbred rats pre-screened for susceptibility to diet-induced obesity. International Journal of Obesity, 32, 1331-1334.

Friedman, M. I. (2007). Obesity and the hepatic control of feeding behavior. Drug News & Perspectives, 20, 573-578.

Ji, H. & Friedman, M. I. (2007). Reduced capacity for fatty acid oxidation in rats with inherited susceptibility to diet-induced obesity. Metabolism: Clinical and Experimental, 56, 1124-1130.

Szymanski, L. A., Schneider, J. E., Friedman, M. I., Ji, H., Kurose, Y., Blache, D. et al. (2007). Changes in insulin, glucose and ketone bodies, but not leptin or body fat content precede restoration of luteinising hormone secretion in ewes. Journal of Neuroendocrinology, 19, 449-460.

Andrews, P. L. R., Friedman, M. I., Liu, Y.-L., Smith, J. E., & Sims, D. W. (2005). Potential energetic implications of emesis in the house musk shrew (Suncus marinus). Physiology & Behavior, 84, 519-524.

Friedman, M. I., Horn, C. C., & Ji, H. (2005). Peripheral signals in the control of feeding behavior. Chemical Senses, 30 Suppl 1, i182-i183.

Horn, C. C. & Friedman, M. I. (2005). Thoracic cross-over pathways of the rat vagal trunks. Brain Research, 1060, 153-161.

Ji, H., Outterbridge, L. V., & Friedman, M. I. (2005). Phenotype-based treatment of dietary obesity: differential effects of fenofibrate in obesity-prone and obesity-resistant rats. Metabolism Clinical and Experimental, 54, 421-429.

Stefan, M., Ji, H., Simmons, R. A., Cummings, D. E., Ahima, R. S., Friedman, M. I. et al. (2005). Hormonal and metabolic defects in a Prader-Willi Syndrome mouse model with neonatal failure to thrive. Endocrinology, 146, 4377-4385.