Contact Information
(267) 519-4867
Michele Dibattista
Postdoctoral Fellow
Education
Ph. D., Neuroscience; International School for Advanced Studies (ISAS/SISSA), Trieste, Italy
Research Summary
In olfaction, the sensitivity of olfactory receptor neurons must allow for detection of signals at behaviorally relevant concentrations and the time course of the response must reliably code changes in odor concentration. My research focuses on the kinetics of vertebrate olfactory signal transduction and how temporal aspects of the odorant-induced response is controlled at the level of olfactory receptor neurons. I will address this question using electrophysiological and immunohistochemical techniques as well as genetically-modified mouse models.
Keywords
olfaction, odor, transduction, ion channels, electrophysiology, neurophysiology, calcium regulation
Recent Publications
Pifferi S*, Dibattista M*, Sagheddu C, Boccaccio A, Al Qteishat A, Ghirardi F, Tirindelli R, Menini A. Calcium-activated chloride currents in olfactory sensory neurons from mice lacking bestrophin-2. J Physiol. 2009 Sep 1;587(Pt 17):4265-79. *These authors contributed equally to this work
Tirindelli R, Dibattista M, Pifferi S, Menini A. From Pheromones to behavior
Physiol Rev. 2009 Jul;89(3):921-56.
Pifferi S, Dibattista M, Menini A. TMEM16B induces chloride currents activated by calcium in mammalian cells. Pflugers Arch. 2009. Epub 2009, May 28.
Dibattista M, Mazzatenta A, Grassi F, Tirindelli R, Menini A. Hyperpolarizationactivated cyclic nucleotide-gated channels in mouse vomeronasal sensory neurons.
J Neurophysiol. 2008 Aug;100(2):576-86.
Corcelli A, Lobasso S, Lopalco P, Dibattista M, Araneda R, Peterlin Z, Firestein S. Detection of explosives by olfactory sensory neurons, J. Hazard. Mater. (2009), doi:10.1016/j.jhazmat.2009.10.05
