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(267) 519-4799
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Paul Wise


Associate Member, Monell Chemical Senses Center
Visiting Professor, Department of Culinary Arts and Food Science, Drexel University


Ph.D., Psychology; University of California, San Diego

Research Summary

Chemical irritation constitutes a continuing focus. In particular, I am interested in how nasal irritation changes over time in the face of steady stimulation, and how one may trade time and concentration to maintain a constant level of detectability to understand how the sensory system integrates over time. Other interests include perception of carbonation, and chemical stimuli as triggers of cough. Within the area of olfaction, my primary interest is mixture interactions in odor detection. An additional interest that cuts across sensory modalities is in methods to measure sensory thresholds.


psychophysics, olfaction, chemesthesis, trigeminal, odor mixtures, dynamics, human perception

Recent Publications

Pelchat, M.L.; Bryant, B.; Cuomo, R.; Di Salle, F.; Fass, R.; Wise, P. (In Press) Carbonation: A review of sensory mechanisms and health effects. Nutrition Today.

Wise, P.M.; Breslin, P.A.S.; Dalton, P.H. (2014) Effect of taste sensation on cough reflex sensitivity. Lung, 192, 9-13.

Wise, P.M.; Bryant, B.P. (2014) The effect of temperature and menthol on carbonation bite. Chemical Senses. (Electronic citation) doi: 10.1093/chemse/bju027

Wise, P.M.; Breslin, P.A.S. (2013) Individual differences in sour and salt sensitivity: Detection and quality recognition thresholds for citric acid and sodium chloride. Chemical Senses. doi: 10.1093/chemse/bjt003

Wise, P.M.; Mennella, J.A.; Finkbeiner, S. (2013) Impaired cough sensitivity in children of smokers. Nicotine and Tobacco Research, 15, 603-607.

Wise, P.M.; Breslin, P.A.S.; Dalton, P. (2012) Sweet taste and menthol increases cough reflex thresholds. Pulmonary Pharmacology and Therapeutics, 25, 236-241.

Wise, P.M.; Wysocki, C.J.; Lundström, J.N. (2012) Stimulus selection for intranasal sensory isolation: eugenol is an irritant. Chemical Senses, 37, 509-514.

Wise, P.M.; Breslin, P.A.S. (2011) Relationships among taste qualities assessed with response-context effects. Chemical Senses, 36, 581-587.

Wise, P.M.; Preti, G.; Eades, J.; Wysocki, C.J. (2011) The effect of menthol vapor on nasal sensitivity to chemical irritation. Nicotine and Tobacco Research, 13, 989-997.

Wise, P.M. (2010) Olfactory Localization. In: Goldstein, B., Sr. (Ed.) Encyclopedia of Perception. Thousand Oaks, Ca: Sage, 1.

Wise, P.M.; Zhao, K.; Wysocki, C. J. (2010) Dynamics of nasal irritation from pulsed, homologous alcohols. Chemical Senses, 35, 823-829.

Miyazawa, T.; Gallagher, M.; Preti. G.; Wise, P. M. (2009) Psychometric functions for ternary odor mixtures and their unmixed components. Chemical Senses, 34, 753-761.

Miyazawa, T.; Gallagher, M.; Preti. G.; Wise, P.M. (2009) Odor detection of mixtures of homologous carboxylic acids and coffee aroma compounds by humans. Journal of Agricultural and Food Chemistry, 57, 9895-9901.

Wise, P.M.; Toczydlowski, S.E.; Zhao, K.; Wysocki, C.J. (2009) Temporal integration in nasal lateralization of homologous propionates. Inhalation Toxicology, 21, 819-827.

Wise, P.M.; Zhao, K.; Wysocki, C.J. (2009) Dynamics of nasal chemesthesis. Annals of the New York Academy of Science, 1170, 206-214.

Miyazawa, T.; Gallagher, M.; Preti, G.; Wise, P.M. (2008) Synergistic mixture interactions in detection of perithreshold odors by humans. Chemical Senses, 33, 363-369.

Miyazawa, T.; Gallagher, M.; Preti, G.; Wise, P.M. (2008) The impact of sub-threshold carboxylic acids on the odor intesity of supra-threshold flavor compounds. Chemosensory Perception, 1, 163-167.

Wise, P.M.; Bien, N.; Wysocki, C.J. (2008) Two rapid odor threshold methods compared to a modified method of constant stimuli. Chemosensory Perception, 1, 16-23.

Wise, P.M.; Hansen, J.L.; Reed, D.R.; Breslin, P.A.S. (2007) Twin study of the heritability of recognition thresholds for sour and salty taste. Chemical Senses, 32, 749-754.

Wise, P.M.; Miyazawa, T.; Gallagher, M.; Preti, G. (2007) Human odor detection of homologous carboxylic acids and their binary mixtures. Chemical Senses, 32, 475-482.

Wise, P.M.; Toczydlowski, S.E.; Wysocki, C.J. (2007) Temporal integration in nasal lateralization of homologous alcohols. Toxicological Sciences, 99, 254-259.