Contact Information

(267) 519-4764
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Makoto Ohmoto

Affiliations

Research Associate, Monell Chemical Senses Center

Laboratory of

Dr. Ichiro Matsumoto

Education

Ph.D., Molecular Biology; University of Tokyo

Research Summary

My primary research interest is to understand mechanisms of ‘non-basic’ tastes. In addition to five basic taste qualities, humans perceive taste of fat, ‘kokumi’ substances, and other non-basic tastes. The function of about a half of taste bud cells remains unclear, and these cells could be involved in reception of these “non-basic” taste substances. I use genetical and molecular biological approaches to reveal cells and genes responsible for these tastes.

Keywords

taste, taste receptor cell, molecular biology, genetics

Recent Publications

Matsumoto, I.; Ohmoto, M.; Narukawa, M.; Yoshihara, Y. and Abe, K. (2011) “Skn-1a (Pou2f3) specifies taste receptor cell lineage.” Nature Neuroscience. 14, 685-7.

Ohmoto, M.; Okada, S.; Nakamura, S.; Abe, K. and Matsumoto, I. (2011) “Mutually exclusive expression of Gαia and Gα14 reveals diversification of taste receptor cells in zebrafish.” Journal of Comparative Neurology. 519, 1616-29.

Ohmoto, M.; Maeda, N.; Abe, K.; Yoshihara, Y.; Matsumoto, I. (2010) “Genetic tracing of the neural pathway for bitter taste in t2r5-WGA transgenic mice.” Biochemical and Biophysical Research Communications. 400, 734-8.

Ohmoto, M.; Matsumoto, I.; Yasuoka, A.; Yoshihara, Y. and Abe, K. (2008) “Genetic tracing of the gustatory and trigeminal neural pathways originating from T1R3-expressing taste receptor cells and solitary chemoreceptor cells.” Molecular and Cellular Neuroscience. 38, 505-17.