Contact Information

(267) 519-4795
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Johannes Reisert

Affiliations

Associate Member, Monell Chemical Senses Center
Co-Chair, Monell Postdoctoral Training Program

Education

Ph.D., Physiology; University of Cambridge

Research Summary

My laboratory investigates one of the first steps in olfactory perception: the conversion of an odorous stimulus into a nerve signal. Olfactory receptor neurons located in the nose detect odorants and generate the electrical response, which is then conveyed to the brain for further processing. The focus of my research is to understand 1) how olfactory receptor neurons code odor signals of different odorants and, 2) the cellular mechanisms that lead to the generation and termination of those responses. We also are interested in investigating the contribution of olfactory receptor neurons to olfactory adaptation, which is the waning of our perception of odorants over time. My approach uses both electrophysiological and cell imaging techniques to address these question.

Detailed description of research program

Keywords

olfaction, single cell electrophysiology, signal transduction, ion channels

Recent Publications

Dibattista, M.; Reisert, J. (2016). The odorant receptor-dependent role of olfactory marker protein in olfactory receptor neurons. The Journal of Neuroscience, 36, 2995-3006.

Pietra, G.; Dibattista, M.; Menini, A.; Reisert, J.; Boccaccio, A. (2016). The Ca2+‐activated Cl channel TMEM16B regulates action potential firing and axonal targeting in olfactory sensory neurons. The Journal of General Physiology, 148, 293-311.

Kato, A.; Reisert, J.; Ihara, S.; Yoshikawa, K.; Touhara, K. (2014) Evaluation of the role of G protein-coupled receptor kinase 3 in desensitization of mouse odorant receptors in a mammalian cell line and in olfactory sensory neuron. Chemical Senses, 39, 771-780.

Mainland, J.D.; Lundström, J.N.; Reisert, J.; Lowe, G. (2014) From molecule to mind: An integrative perspective on odor intensity. Trends in Neuroscience, 1062, 1-12.

Li, F.; Ponissery Saidu, S.; Yee, K.K.; Wang, H.; Chen, M.L.; Iguchi, N.; Zhang, G.; Jiang, P.; Reisert, J.; Huang, L. (2013) Heterotrimeric G protein subunit Ggamma13 is critical to olfaction. Journal of Neuroscience, 33, 7975-7984.

Reisert, J.; Golden, G.J.; Matsumura, K.; Smear, M.; Rinberg, D.; Gelperin A. (2013) Comparing thoracic and intra-nasal pressure transients to monitor active odor sampling during odor-guided decision making in the mouse. Journal of Neuroscience Methods, 221, 8-14.

Ponissery Saidu, S.; Dibattista, M.; Matthews, H.R.;Reisert, J. (2012) Odorant-induced responses recorded from olfactory receptor neurons using the suction pipette technique. Journal of Visualized Experiments : JoVE, 62, e3862.

Stephan, A.B.; Tobochnik, S.; Dibattista, M.; Wall, C.M.; Reisert, J.; Zhao, H. (2012) The Na+/Ca2+ exchanger NCKX4 governs termination and adaptation of the mammalian olfactory response. Nature Neuroscience, 15, 131-137.

Su, C.Y.; Menuz, K.; Reisert, J.; Carlson, J.R. (2012) Non-synaptic inhibition between grouped neurons in an olfactory circuit. Nature, 492, 66-71.

Ghatpande, A.S.; Reisert, J. (2011) Olfactory receptor neuron responses coding for rapid odor sampling. Journal of Physiology, 589, 2261-2273.

Reisert, J. (2010) Origin of basal activity in mammalian olfactory receptor neurons. Journal of General Physiology, 136, 529-540.

Stephan, A.B.; Shum, E.Y.; Hirsh, S.; Cygnar, K.D.; Reisert, J.; Zhao, H. (2009) ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification. Proceedings National Academy of Sciences USA, 106, 11776-11781.

Reviews, Book Chapters and Perspectives

Reisert, J..; Gelperin, A. (2012) When does more give less in the olfactory system? Physiology News, 86, 18-21.

Reisert, J.; Zhao, H. (2011) Perspectives on: Information and coding in mammalian sensory physiology: Response kinetics of olfactory receptor neurons and the implications in olfactory coding. Journal of General Physiology, 138, 303-310.

Reisert, J.; Restrepo, D. (2009) Molecular tuning of odorant receptors and its implication for odor signal processing. Chemical Senses, 34, 535-545.

Reisert, J.; Margolis, F.L. (2008) Olfactory marker protein: a gift to molecular biologists, an enigma to physiologists. Physiology News, 73, 27-29.

Bradley, J.; Reisert, J.; Frings, S. (2005) Regulation of cyclic nucleotide-gated channels. Current Opinions in Neurobiology, 15, 343-349.

Matthews, H.R.; Reisert, J. (2003) Calcium, the two-faced messenger of olfactory transduction and adaptation. Current Opinions in Neurobiology, 13, 469-475.